Managing Common GLP-1 Side Effects
Most side effects are GI-related, most are worst in the first weeks, and most have practical workarounds.
Nausea
The most common complaint, especially in the 48 hours after a dose increase. Smaller meals, avoiding greasy or very sweet food, and stopping eating when you first feel full all help. Many clinicians will hold a dose level longer rather than escalate on schedule if nausea persists.
Constipation
Slower digestion plus eating less means less throughput. Fibre, fluids, and movement are the first line; an over-the-counter osmotic laxative is commonly recommended if that isn't enough.
Fatigue and low appetite
Under-eating is easy when you aren't hungry. Aim for protein at every meal to protect muscle mass, and don't skip meals entirely even when appetite is low.
When to contact your clinician
- Severe or persistent abdominal pain, especially radiating to the back
- Vomiting that prevents you keeping fluids down for more than a day
- Signs of gallbladder trouble: pain in the upper right abdomen, fever, yellowing skin
- Vision changes if you have diabetes
Good telehealth programs make this easy: unlimited messaging with a clinician is one of the most useful things to compare when choosing one. See our program reviews.
A different format or a slower titration may suit you better. Our check factors in your history.
Start the check →This article is informational and not medical advice. Contact your clinician or emergency services for urgent symptoms. Medical disclaimer